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PDBsum entry 3eol

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protein ligands Protein-protein interface(s) links
Lyase PDB id
3eol
Jmol PyMol
Contents
Protein chains
362 a.a. *
Ligands
GOL
PEG ×2
Waters ×224
* Residue conservation analysis
PDB id:
3eol
Name: Lyase
Title: 2.0a crystal structure of isocitrate lyase from brucella mel (p43212)
Structure: Isocitrate lyase. Chain: a, b. Engineered: yes
Source: Brucella melitensis. Organism_taxid: 29459. Strain: biovar abortus 2308. Gene: bmei0409. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.00Å     R-factor:   0.223     R-free:   0.263
Authors: Seattle Structural Genomics Center For Infectious Disease (S
Key ref: Ssgcid Crystal structures of isocitrate lyase from brucella melitensis. To be published, .
Date:
28-Sep-08     Release date:   21-Oct-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q2YQA0  (Q2YQA0_BRUA2) -  Isocitrate lyase
Seq:
Struc:
429 a.a.
362 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.4.1.3.1  - Isocitrate lyase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Glyoxylate Cycle
      Reaction: Isocitrate = succinate + glyoxylate
Isocitrate
= succinate
+
glyoxylate
Bound ligand (Het Group name = GOL)
matches with 57.14% similarity
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     carboxylic acid metabolic process   1 term 
  Biochemical function     catalytic activity     3 terms  

 

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