UniProt functional annotation for P20432

UniProt code: P20432.

Organism: Drosophila melanogaster (Fruit fly).
Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. {ECO:0000269|PubMed:20417639}.
Catalytic activity: RX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:20417639}.
Catalytic activity: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride. {ECO:0000269|PubMed:20417639}.
Subunit: Homodimer. {ECO:0000269|PubMed:20417639}.
Miscellaneous: Has a specific activity toward 1-chloro-2,4- dinitrobenzene comparable to that for the mammalian glutathione S- transferases but did not have as broad a substrate specificity pattern. Has no GSH peroxidase activity.
Similarity: Belongs to the GST superfamily. Theta family. {ECO:0000305}.
Similarity: Contains 1 GST C-terminal domain. {ECO:0000305}.
Similarity: Contains 1 GST N-terminal domain. {ECO:0000305}.
Sequence caution: Sequence=AAM52032.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.