UniProt functional annotation for P52917



	UniProt functional annotation for P52917

UniProt code: P52917.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. {ECO:0000269|PubMed:11329380, ECO:0000269|PubMed:9155008, ECO:0000269|PubMed:9606181}.

Subunit: Monomer or homodimer (in nucleotide-free form). Decamer, dodecamer or tetradecamer of two stacked respective homooligomeric rings (when bound to ATP); the dodecameric form seems to be predominant. Interacts with VPS20. Interacts with VTA1; the interaction requires the dimeric structure of VTA1; 6 homodimers of VTA1 appear to associate with the dodecameric VSP4 complex. Interacts with DID2. Interacts with DID4. Interacts with IST1; IST1 competes with VTA1 for binding with VPS4. {ECO:0000269|PubMed:12953057, ECO:0000269|PubMed:15086794, ECO:0000269|PubMed:16505166, ECO:0000269|PubMed:16601096, ECO:0000269|PubMed:17130288, ECO:0000269|PubMed:17928861, ECO:0000269|PubMed:17949747, ECO:0000269|PubMed:18032584, ECO:0000269|PubMed:18280501, ECO:0000269|PubMed:9606181}.

Subcellular location: Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Miscellaneous: Present with 5350 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Similarity: Belongs to the AAA ATPase family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. {ECO:0000269\|PubMed:11329380, ECO:0000269\|PubMed:9155008, ECO:0000269\|PubMed:9606181}.


Subunit:		Monomer or homodimer (in nucleotide-free form). Decamer, dodecamer or tetradecamer of two stacked respective homooligomeric rings (when bound to ATP); the dodecameric form seems to be predominant. Interacts with VPS20. Interacts with VTA1; the interaction requires the dimeric structure of VTA1; 6 homodimers of VTA1 appear to associate with the dodecameric VSP4 complex. Interacts with DID2. Interacts with DID4. Interacts with IST1; IST1 competes with VTA1 for binding with VPS4. {ECO:0000269\|PubMed:12953057, ECO:0000269\|PubMed:15086794, ECO:0000269\|PubMed:16505166, ECO:0000269\|PubMed:16601096, ECO:0000269\|PubMed:17130288, ECO:0000269\|PubMed:17928861, ECO:0000269\|PubMed:17949747, ECO:0000269\|PubMed:18032584, ECO:0000269\|PubMed:18280501, ECO:0000269\|PubMed:9606181}.
Subcellular location:		Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Miscellaneous:		Present with 5350 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity:		Belongs to the AAA ATPase family. {ECO:0000305}.