PDBsum entry 3eac

Transferase

PDB id: 3eac

Contents

Protein chain

101 a.a. *

Waters ×106

* Residue conservation analysis

PDB id:

3eac

Name:

Transferase

Title:

Crystal structure of sh2 domain of human csk (carboxyl-terminal src kinase), oxidized form.

Structure:

Tyrosine-protein kinase csk. Chain: a. Fragment: sh2 domain (unp residues 73 to 178). Synonym: c-src kinase, protein-tyrosine kinase cyl. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21(de3). Gene: csk. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.37Å R-factor: 0.209 R-free: 0.217

Authors:

D.Liu,R.D.Seidel,D.Cowburn

Key ref:

D.Liu and D.Cowburn (2016). Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep, 2, 33-43. PubMed id: 27819029 DOI: 10.1007/s41048-016-0025-4

Date:

25-Aug-08 Release date: 10-Nov-09

Protein chain

P41240  (CSK_HUMAN) -  Tyrosine-protein kinase CSK from Homo sapiens

Seq: 450 a.a.

Struc: 101 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1007/s41048-016-0025-4

Biophys Rep 2:33-43 (2016)

PubMed id: 27819029

Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.

D.Liu, D.Cowburn.

ABSTRACT

No abstract given.