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PDBsum entry 3e8c
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Contents |
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(+ 0 more)
344 a.a.
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18 a.a.
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20 a.a.
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19 a.a.
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19 a.a.
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References listed in PDB file
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Key reference
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Title
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Aminofurazans as potent inhibitors of akt kinase.
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Authors
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M.B.Rouse,
M.A.Seefeld,
J.D.Leber,
K.C.Mcnulty,
L.Sun,
W.H.Miller,
S.Zhang,
E.A.Minthorn,
N.O.Concha,
A.E.Choudhry,
M.D.Schaber,
D.A.Heerding.
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Ref.
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Bioorg Med Chem Lett, 2009,
19,
1508-1511.
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PubMed id
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Abstract
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AKT inhibitors containing an imidazopyridine aminofurazan scaffold have been
optimized. We have previously disclosed identification of the AKT inhibitor
GSK690693, which has been evaluated in clinical trials in cancer patients.
Herein we describe recent efforts focusing on investigating a distinct region of
this scaffold that have afforded compounds (30 and 32) with comparable activity
profiles to that of GSK690693.
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Secondary reference #1
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Title
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Discovery of 5-Pyrrolopyridinyl-2-Thiophenecarboxamides as potent akt kinase inhibitors
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Authors
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M.A.Seefeld,
M.B.Rouse,
K.C.Mcnulty,
L.Sun,
J.Wang,
D.S.Yamashita,
A.Choudhry,
M.D.Schaber,
R.Kumar,
J.Kahana,
S.Y.Zhang,
E.A.Minthorn,
K.K.Koretke,
N.O.Concha,
D.A.Heerding.
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Ref.
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To be Published ...
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