PDBsum entry 3e4u

Transcription

PDB id: 3e4u

Contents

Protein chains

119 a.a.

120 a.a.

112 a.a.

110 a.a.

Waters ×256

References listed in PDB file

Key reference

• Title: Structure of the wild-Type human bcl6 poz domain.
• Authors: M.A.Stead, G.O.Rosbrook, J.M.Hadden, C.H.Trinh, S.B.Carr, S.C.Wright.
• Ref.: Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008, 64, 1101-1104.
• PubMed id: 19052359

Abstract

BCL6 is a transcriptional repressor that is overexpressed in diffuse large B-cell lymphoma and follicular lymphoma. The N-terminal POZ domain of BCL6 interacts with transcriptional corepressors and targeting these associations is a promising therapeutic strategy. Previous structural studies of the BCL6 POZ domain have used a mutant form because of the low solubility of the wild-type recombinant protein. A method for the purification and crystallization of the wild-type BCL6 POZ domain is described and the crystal structure to 2.1 A resolution is reported. This will be relevant for the design of therapeutics that target BCL6 POZ-domain interaction interfaces.