UniProt functional annotation for P63151



	UniProt functional annotation for P63151

UniProt code: P63151.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:33108758}.

Subunit: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TP53 (PubMed:17245430). Interacts with IER5 (PubMed:25816751). Interacts with MFHAS1; the interaction is direct (PubMed:28609714). Interacts with PABIR1/FAM122A (PubMed:27588481, PubMed:33108758). Interacts with CRTC3 (PubMed:30611118). {ECO:0000250, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:25816751, ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:28609714, ECO:0000269|PubMed:30611118, ECO:0000269|PubMed:33108758}.

Tissue specificity: Expressed in all tissues examined. {ECO:0000269|PubMed:1849734}.

Similarity: Belongs to the phosphatase 2A regulatory subunit B family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000269\|PubMed:33108758}.


Subunit:		Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TP53 (PubMed:17245430). Interacts with IER5 (PubMed:25816751). Interacts with MFHAS1; the interaction is direct (PubMed:28609714). Interacts with PABIR1/FAM122A (PubMed:27588481, PubMed:33108758). Interacts with CRTC3 (PubMed:30611118). {ECO:0000250, ECO:0000269\|PubMed:17245430, ECO:0000269\|PubMed:25816751, ECO:0000269\|PubMed:27588481, ECO:0000269\|PubMed:28609714, ECO:0000269\|PubMed:30611118, ECO:0000269\|PubMed:33108758}.
Tissue specificity:		Expressed in all tissues examined. {ECO:0000269\|PubMed:1849734}.
Similarity:		Belongs to the phosphatase 2A regulatory subunit B family. {ECO:0000305}.