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PDBsum entry 3dv3
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References listed in PDB file
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Key reference
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Title
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Beyond the mek-Pocket: can current mek kinase inhibitors be utilized to synthesize novel type III nckis? does the mek-Pocket exist in kinases other than mek?
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Authors
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H.Tecle,
J.Shao,
Y.Li,
M.Kothe,
S.Kazmirski,
J.Penzotti,
Y.H.Ding,
J.Ohren,
D.Moshinsky,
R.Coli,
N.Jhawar,
E.Bora,
S.Jacques-O'Hagan,
J.Wu.
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Ref.
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Bioorg Med Chem Lett, 2009,
19,
226-229.
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PubMed id
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Abstract
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An approach and preliminary results for utilizing legacy MEK inhibitors as
templates for a reiterative structural based design and synthesis of novel, type
III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided
that the MEK-pocket or pockets closely related to it may exist in kinases other
than MEK.
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