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PDBsum entry 3dtu

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Oxidoreductase PDB id
3dtu
Jmol
Contents
Protein chains
539 a.a.
259 a.a.
Ligands
DMU ×9
_OH ×2
PO4 ×2
HEA ×4
TRD ×23
HTO
DXC
Metals
_CU ×6
_MG ×2
_CA ×2
_CD ×5
Waters ×636

References listed in PDB file
Key reference
Title A conserved steroid binding site in cytochrome c oxidase.
Authors L.Qin, D.A.Mills, L.Buhrow, C.Hiser, S.Ferguson-Miller.
Ref. Biochemistry, 2008, 47, 9931-9933.
PubMed id 18759498
Abstract
Micromolar concentrations of the bile salt deoxycholate are shown to rescue the activity of an inactive mutant, E101A, in the K proton pathway of Rhodobacter sphaeroides cytochrome c oxidase. A crystal structure of the wild-type enzyme reveals, as predicted, deoxycholate bound with its carboxyl group at the entrance of the K path. Since cholate is a known potent inhibitor of bovine oxidase and is seen in a similar position in the bovine structure, the crystallographically defined, conserved steroid binding site could reveal a regulatory site for steroids or structurally related molecules that act on the essential K proton path.
PROCHECK
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 Headers