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UniProt functional annotation for O93523 | ||
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| UniProt code: O93523. |
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| Organism: | |
Bothrops jararaca (Jararaca) (Bothrops jajaraca). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops. |
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| Function: | |
[Zinc metalloproteinase-disintegrin-like bothropasin]: has caseinolytic activity. Causes hemorrhage on rabbit skin and causes myonecrosis in mouse tibialis anterior muscle. |
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| Function: | |
[Disintegrin-like bothropasin]: inhibits platelet aggregation. |
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| Catalytic activity: | |
Reaction=Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 in insulin B chain.; EC=3.4.24.49; Evidence={ECO:0000269|PubMed:6819660}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:18831982}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:18831982}; |
| Activity regulation: | |
Inhibited by EDTA and EGTA. {ECO:0000269|PubMed:6819660}. |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:18831982, ECO:0000269|PubMed:6819660}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Miscellaneous: | |
The metalloproteinase domain which is released from the cleavage of the disintegrin bothropasin may be unstable. |
| Similarity: | |
Belongs to the venom metalloproteinase (M12B) family. P-III subfamily. P-IIIb sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.