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UniProt functional annotation for Q9NXV2 | ||
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| UniProt code: Q9NXV2. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (PubMed:18573101). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (PubMed:19361449). {ECO:0000269|PubMed:18573101, ECO:0000269|PubMed:19361449}. |
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| Subunit: | |
Homopentamer (PubMed:19361449). Interacts (via C-terminus) with GRASP55/GORASP2 (PubMed:19361449). Interacts with CUL3 and with ubiquitinated proteins (PubMed:18573101). Interacts with CRY1 (By similarity). {ECO:0000250|UniProtKB:Q8VC57, ECO:0000269|PubMed:18573101, ECO:0000269|PubMed:19361449}. |
| Subunit: | |
(Microbial infection) Interacts with adeno-associated virus 2 (AAV-2) REP proteins. {ECO:0000269|PubMed:17239418}. |
| Subcellular location: | |
Cytoplasm, cytosol {ECO:0000269|PubMed:17239418}. Cytoplasm {ECO:0000269|PubMed:18573101}. Nucleus. Note=Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins. {ECO:0000269|PubMed:18573101}. |
| Induction: | |
Up-regulated in peripheral blood lymphocytes stimulated through the T-cell receptor. {ECO:0000269|PubMed:18573101}. |
| Domain: | |
The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer (PubMed:19361449). Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118. {ECO:0000269|PubMed:19361449}. |
Annotations taken from UniProtKB at the EBI.