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PDBsum entry 3dnd
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protein ligands Protein-protein interface(s) links
Transferase/transferase inhibitor PDB id
3dnd

 

 

 

 

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Contents
Protein chains
336 a.a. *
20 a.a. *
Ligands
LL2
Waters ×264
* Residue conservation analysis
PDB id:
3dnd
Name: Transferase/transferase inhibitor
Title: Camp-dependent protein kinase pka catalytic subunit with pki-5-24
Structure: Camp-dependent protein kinase catalytic subunit alpha. Chain: a. Synonym: pka c-alpha. Engineered: yes. Camp-dependent protein kinase inhibitor alpha. Chain: i. Fragment: inhibitory fragment, unp residues 6-25. Synonym: camp-dependent protein kinase inhibitor, muscle/brain isoform, pki-alpha.
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic construct
Resolution:
2.26Å     R-factor:   0.193     R-free:   0.253
Authors: A.Schiffer,K.U.Wendt
Key ref: J.Orts et al. (2008). Crystallography-independent determination of ligand binding modes. Angew Chem Int Ed Engl, 47, 7736-7740. PubMed id: 18767090
Date:
02-Jul-08     Release date:   23-Jun-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00517  (KAPCA_BOVIN) -  cAMP-dependent protein kinase catalytic subunit alpha from Bos taurus
Seq:
Struc: 		351 a.a.
336 a.a.*
Protein chain
Pfam   ArchSchema ?
P61926  (IPKA_RABIT) -  cAMP-dependent protein kinase inhibitor alpha from Oryctolagus cuniculus
Seq:
Struc: 		76 a.a.
20 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chain A: E.C.2.7.11.11  - cAMP-dependent protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction:
1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
L-seryl-[protein]
 + ATP
 = O-phospho-L-seryl-[protein]
 + ADP
 + H(+)
L-threonyl-[protein]
 + ATP
 = O-phospho-L-threonyl-[protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
Angew Chem Int Ed Engl 47:7736-7740 (2008)
PubMed id: 18767090  
 
 
Crystallography-independent determination of ligand binding modes.
J.Orts, J.Tuma, M.Reese, S.K.Grimm, P.Monecke, S.Bartoschek, A.Schiffer, K.U.Wendt, C.Griesinger, T.Carlomagno.
 
  ABSTRACT  
 
No abstract given.

 

 

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