PDBsum entry 3dk6

Transferase

PDB id: 3dk6

Contents

Protein chains

263 a.a. *

Ligands

SX7 ×2

Waters ×278

* Residue conservation analysis

PDB id:

3dk6

Name:

Transferase

Title:

Crystal structure of mutant abl kinase domain in complex with small molecule fragment

Structure:

Proto-oncogene tyrosine-protein kinase abl1. Chain: a, b. Synonym: abelson murine leukemia viral oncogene homolog 1, c-abl, p150. Engineered: yes. Mutation: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl1, abl. Expressed in: escherichia coli

Resolution:

2.02Å R-factor: 0.216 R-free: 0.246

Authors:

H.A.Lewis

Key ref:

P.-Y.Bounaud et al. Crystal structure of mutant abl kinase domain in complex with small molecule fragment. To be published, .

Date:

24-Jun-08 Release date: 29-Jul-08

Protein chains

P00520  (ABL1_MOUSE) -  Tyrosine-protein kinase ABL1 from Mus musculus

Seq: 1123 a.a.

Struc: 263 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site