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PDBsum entry 3dj6
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Crystal structure of the mouse aurora-a catalytic domain (asn186->gly, lys240->arg, met302->leu) in complex with compound 823.
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Structure:
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Serine/threonine kinase 6. Chain: a. Fragment: aurora a kinase domain, unp residues 116-382. Synonym: aurora-a kinase. Engineered: yes. Mutation: yes
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Source:
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Mus musculus. Mouse. Organism_taxid: 10090. Gene: aurka, stk6. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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1.70Å
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R-factor:
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0.217
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R-free:
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0.261
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Authors:
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R.A.Elling,D.A.Erlanson,W.Yang,B.T.Tangonan,S.K.Hansen,M.J.Romanowski
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Key ref:
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R.A.Elling
et al.
New fragment-Based drug discovery.
To be published,
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Date:
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22-Jun-08
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Release date:
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05-May-09
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PROCHECK
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Headers
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References
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P97477
(AURKA_MOUSE) -
Aurora kinase A from Mus musculus
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Seq:
Struc:
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395 a.a.
252 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 3 residue positions (black
crosses)
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Enzyme class:
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E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
