PDBsum entry 3dgk

Transferase

PDB id: 3dgk

Contents

Protein chain

278 a.a. *

Waters ×222

* Residue conservation analysis

PDB id:

3dgk

Name:

Transferase

Title:

Crystal structure of a glycine-rich loop mutant of the death associated protein kinase catalytic domain

Structure:

Death-associated protein kinase 1. Chain: a. Fragment: protein kinase catalytic domain. Synonym: dap kinase 1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dapk1, dapk. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.70Å R-factor: 0.175 R-free: 0.220

Authors:

L.K.Mcnamara,J.P.Schavocky,D.M.Watterson,J.S.Brunzelle

Key ref:

L.K.Mcnamara et al. High resolution crystal structures of the death associated protein kinase catalytic domain with a key point mutation in the glycine-Rich loop. To be published, .

Date:

13-Jun-08 Release date: 26-May-09

Protein chain

P53355  (DAPK1_HUMAN) -  Death-associated protein kinase 1 from Homo sapiens

Seq: 1430 a.a.

Struc: 278 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site