|
|
||
|
|
|
|
|
UniProt functional annotation for P08560 | ||
|
|
|
|
|
|
||
| UniProt code: P08560. |
|
||
| Organism: | |
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus. |
|
||
|
||
| Function: | |
Plays a role in the protection against host NK cell cytotoxicity by interacting with and modulating the activity of the host inhibitory leukocyte Ig-like receptor 1/LILRB1, which is expressed on monocytes, dendritic cells, as well as subsets of T and NK cells. UL18 exerts an inhibitory effect on LIR-1+ NK cells, while it stimulates LIR-1- NK cell. These modulations prevent lysis of the infected cells by NK cells. {ECO:0000269|PubMed:18688275}. |
|
||
| Subunit: | |
Interacts with host LILRB1. {ECO:0000269|PubMed:10591185}. |
| Subcellular location: | |
Host membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.