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UniProt functional annotation for Q9ES67 | ||
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| UniProt code: Q9ES67. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:11242047}. |
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| Subunit: | |
Interacts with RHOA, GNA13 and SLC1A6. Interacts with GNA12, PLXNB1 and PLXNB2 (By similarity). Interacts (via DH domain) with GCSAM (via C-terminus) (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Translocated to the membrane upon stimulation. {ECO:0000250}. |
| Ptm: | |
Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14). {ECO:0000250}. |
| Ptm: | |
Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex when previously phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14), leading to its degradation, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth. {ECO:0000250}. |
Annotations taken from UniProtKB at the EBI.