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PDBsum entry 3cpw
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Contents |
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237 a.a.
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337 a.a.
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246 a.a.
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140 a.a.
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172 a.a.
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119 a.a.
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29 a.a.
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160 a.a.
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142 a.a.
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132 a.a.
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145 a.a.
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194 a.a.
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186 a.a.
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115 a.a.
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143 a.a.
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95 a.a.
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150 a.a.
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81 a.a.
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119 a.a.
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53 a.a.
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65 a.a.
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154 a.a.
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82 a.a.
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142 a.a.
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72 a.a.
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56 a.a.
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46 a.a.
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92 a.a.
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 _SR
×108
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 _NA
×75
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 _CL
×22
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 _CD
×5
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_MG
×92
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 __K
×2
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References listed in PDB file
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Key reference
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Title
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Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50s ribosomal subunit.
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Authors
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J.A.Ippolito,
Z.F.Kanyo,
D.Wang,
F.J.Franceschi,
P.B.Moore,
T.A.Steitz,
E.M.Duffy.
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Ref.
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J Med Chem, 2008,
51,
3353-3356.
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PubMed id
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Abstract
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The oxazolidinone antibacterials target the 50S subunit of prokaryotic
ribosomes. To gain insight into their mechanism of action, the crystal structure
of the canonical oxazolidinone, linezolid, has been determined bound to the
Haloarcula marismortui 50S subunit. Linezolid binds the 50S A-site, near the
catalytic center, which suggests that inhibition involves competition with
incoming A-site substrates. These results provide a structural basis for the
discovery of improved oxazolidinones active against emerging drug-resistant
clinical strains.
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