UniProt functional annotation for P10970

UniProt code: P10970.

Organism: Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui).
Taxonomy: Archaea; Euryarchaeota; Halobacteria; Halobacteriales; Halobacteriaceae; Haloarcula.
Function: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. {ECO:0000255|HAMAP- Rule:MF_01331}.
Function: Contacts all 6 domains of the 23S rRNA, helping stabilize their relative orientation. An extended beta-hairpin in the C-terminus forms part of the polypeptide exit tunnel, in which it helps forms a bend with protein L4, while most of the rest of the protein is located at the polypeptide exit tunnel on the outside of the subunit.
Subunit: Part of the 50S ribosomal subunit. Contacts the macrolide antibiotic tylosin in the polypeptide exit tunnel. {ECO:0000255|HAMAP-Rule:MF_01331, ECO:0000269|PubMed:12150912, ECO:0000269|PubMed:12860128}.
Similarity: Belongs to the ribosomal protein L22P family. {ECO:0000255|HAMAP-Rule:MF_01331}.

Annotations taken from UniProtKB at the EBI.