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UniProt functional annotation for Q01083 | ||
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| UniProt code: Q01083. |
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| Organism: | |
Drosophila melanogaster (Fruit fly). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
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| Function: | |
Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination. {ECO:0000269|PubMed:7833286}. |
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| Subunit: | |
Interacts with Star via the lumenal domain. {ECO:0000269|PubMed:18500331}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:11672524}; Single-pass type I membrane protein {ECO:0000269|PubMed:11672524}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11672524}; Single- pass type I membrane protein {ECO:0000269|PubMed:11672524}. Golgi apparatus membrane {ECO:0000269|PubMed:11672524}; Single-pass type I membrane protein {ECO:0000269|PubMed:11672524}. Note=Relocalization to the Golgi apparatus and the plasma membrane is mediated by Star. In the presence of Rhomboid, Spitz is found only in the Golgi, not at the cell surface. |
| Tissue specificity: | |
Expressed throughout the embryo. |
| Ptm: | |
Proteolytic processing by Rhomboid occurs in the Golgi. Cleavage takes place within the transmembrane domain close to residue 144 and the active growth factor is released. {ECO:0000269|PubMed:11672524}. |
| Ptm: | |
N-glycosylated and O-glycosylated. |
| Sequence caution: | |
Sequence=AAA28894.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.