UniProt functional annotation for Q00805



	UniProt functional annotation for Q00805

UniProt code: Q00805.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: Regulates cell determination; development of ommatidia and optic lobe. Is a signaling molecule involved in the process of axon pathfinding in the eye. Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz). Antagonist for the Egfr receptor (gurken). Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr- activating ligand spitz (spi). {ECO:0000269|PubMed:10200472, ECO:0000269|PubMed:1286772, ECO:0000269|PubMed:15329724, ECO:0000269|PubMed:15879554, ECO:0000269|PubMed:1606617, ECO:0000269|PubMed:1628618}.

Subunit: Interacts with spi. {ECO:0000269|PubMed:15329724, ECO:0000269|PubMed:18500331}.

Subcellular location: Secreted {ECO:0000269|PubMed:1606617}.

Tissue specificity: During embryogenesis, expression is in a segmental pattern in the ectoderm and in the nervous system. In the eye imaginal disks, expression in photoreceptor cells begins a few rows posterior to the morphogenetic furrow. Also expressed in the wing disk. In the adult, expression is seen in the retina and lamina. {ECO:0000269|PubMed:1286772}.

Domain: The three two-fingered repeats tightly encircle spi, providing the basis for it's sequestration. The first repeat harbors a 120 AA insert specific to drosophilidae.

Disruption phenotype: Flies exhibit transformation of the eye mystery cells, which are usually non-neuronal, into extra photoreceptors, and supernumerary cone cells and pigment cells are also recruited. Mutants also exhibit abnormal head involution, a change in a number of sensilla in the antennomaxillary complex and abnormal morphogenesis of the maxillary palp and wings in later stages. {ECO:0000269|PubMed:1606617}.

Sequence caution: Sequence=AAM52736.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		Regulates cell determination; development of ommatidia and optic lobe. Is a signaling molecule involved in the process of axon pathfinding in the eye. Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz). Antagonist for the Egfr receptor (gurken). Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr- activating ligand spitz (spi). {ECO:0000269\|PubMed:10200472, ECO:0000269\|PubMed:1286772, ECO:0000269\|PubMed:15329724, ECO:0000269\|PubMed:15879554, ECO:0000269\|PubMed:1606617, ECO:0000269\|PubMed:1628618}.


Subunit:		Interacts with spi. {ECO:0000269\|PubMed:15329724, ECO:0000269\|PubMed:18500331}.
Subcellular location:		Secreted {ECO:0000269\|PubMed:1606617}.
Tissue specificity:		During embryogenesis, expression is in a segmental pattern in the ectoderm and in the nervous system. In the eye imaginal disks, expression in photoreceptor cells begins a few rows posterior to the morphogenetic furrow. Also expressed in the wing disk. In the adult, expression is seen in the retina and lamina. {ECO:0000269\|PubMed:1286772}.
Domain:		The three two-fingered repeats tightly encircle spi, providing the basis for it's sequestration. The first repeat harbors a 120 AA insert specific to drosophilidae.
Disruption phenotype:		Flies exhibit transformation of the eye mystery cells, which are usually non-neuronal, into extra photoreceptors, and supernumerary cone cells and pigment cells are also recruited. Mutants also exhibit abnormal head involution, a change in a number of sensilla in the antennomaxillary complex and abnormal morphogenesis of the maxillary palp and wings in later stages. {ECO:0000269\|PubMed:1606617}.
Sequence caution:		Sequence=AAM52736.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};