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UniProt functional annotation for P97428 | ||
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| UniProt code: P97428. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Regulates G protein-coupled receptor signaling cascades (PubMed:9079700). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10373502). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha (PubMed:8917514). May regulate extra and intracellular mitogenic signals. {ECO:0000269|PubMed:10373502, ECO:0000269|PubMed:8917514, ECO:0000305}. |
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| Subunit: | |
Interacts with GNAI1 and GNAQ (By similarity). Interacts with GNAI3, GNAI3 and GNAO1 (PubMed:9079700, PubMed:18434540). {ECO:0000250|UniProtKB:O15492, ECO:0000269|PubMed:18434540, ECO:0000269|PubMed:9079700}. |
| Subcellular location: | |
Membrane {ECO:0000269|PubMed:10373502}; Lipid- anchor {ECO:0000269|PubMed:10373502}. |
| Tissue specificity: | |
Retinal; also predominantly expressed in the liver and pituitary. |
| Ptm: | |
Palmitoylated on Cys-2 and/or Cys-12. {ECO:0000269|PubMed:10373502}. |
| Ptm: | |
Phosphorylated. Phosphorylation at Tyr-167 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1. {ECO:0000250|UniProtKB:O15492}. |
Annotations taken from UniProtKB at the EBI.