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UniProt functional annotation for P18872 | ||
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| UniProt code: P18872. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Stimulated by RGS14. The G(o) protein function is not clear. {ECO:0000269|PubMed:10926822}. |
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| Subunit: | |
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS14. {ECO:0000269|PubMed:10926822}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:15585744}. Membrane {ECO:0000250|UniProtKB:P09471}; Lipid-anchor {ECO:0000250|UniProtKB:P09471}. |
| Ptm: | |
Histaminylated at Gln-205 residues by TGM2. {ECO:0000269|PubMed:23022564}. |
| Similarity: | |
Belongs to the G-alpha family. G(i/o/t/z) subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.