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UniProt functional annotation for Q570C0 | ||
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| UniProt code: Q570C0. |
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| Organism: | |
Arabidopsis thaliana (Mouse-ear cress). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. |
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| Function: | |
Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae. {ECO:0000269|PubMed:10398681, ECO:0000269|PubMed:12606727, ECO:0000269|PubMed:15917797, ECO:0000269|PubMed:15917798, ECO:0000269|PubMed:15992545, ECO:0000269|PubMed:16627744, ECO:0000269|PubMed:18391211, ECO:0000269|PubMed:9436980}. |
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| Pathway: | |
Protein modification; protein ubiquitination. |
| Subunit: | |
Interacts with auxin. Part of a SCF E3 ubiquitin ligase complex SCF(TIR1) composed of SKP1, CUL1, RBX1 and TIR1. SCF(TIR1) interacts with the COP9 signalosome (CSN) complex. Interacts with Aux/IAA proteins (IAA3, IAA7, IAA12 and IAA17) in an auxin-dependent manner. The interaction with IAA3, a negative regulator of auxin responses, is promoted by auxin, but repressed by juglon (5-hydroxy- 1,4-naphthoquinone). Interactions with auxin-responsive proteins is inactivated by auxin antagonists. {ECO:0000269|PubMed:10398681, ECO:0000269|PubMed:11337587, ECO:0000269|PubMed:11713520, ECO:0000269|PubMed:12215511, ECO:0000269|PubMed:14617065, ECO:0000269|PubMed:15917797, ECO:0000269|PubMed:15917798, ECO:0000269|PubMed:15992545, ECO:0000269|PubMed:17410169, ECO:0000269|PubMed:18391211}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:15992545}. |
| Tissue specificity: | |
Expressed in roots, stems, leaves and flowers. In adult plants, mostly expressed in floral stigma, anther filaments, abscission zones and vascular tissues. {ECO:0000269|PubMed:10398681, ECO:0000269|PubMed:9436980}. |
| Developmental stage: | |
Abundant expression in developing embryos. In young seedlings, expressed in root apical meristem, and expanding cotyledons and hypocotyls. In older seedlings, still expressed in root apical meristems, but also in lateral root primordia, stipules, shoot apical meristem and vascular tissues. {ECO:0000269|PubMed:10398681}. |
| Induction: | |
Repressed by miR393a (microRNA) in response to flg-22 (flagellin-derived peptide 22). {ECO:0000269|PubMed:16627744}. |
| Domain: | |
The F-box is necessary for the interaction with SKP1. {ECO:0000269|PubMed:10398681}. |
| Disruption phenotype: | |
Plant are deficient in a variety of auxin- regulated growth processes including lateral root formation, and hypocotyl and cell elongation. {ECO:0000269|PubMed:9436980}. |
| Miscellaneous: | |
The myo-inositol hexakisphosphate acts as a structural cofactor. |
| Sequence caution: | |
Sequence=BAD94031.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.