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PDBsum entry 3c27
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protein ligands Protein-protein interface(s) links
Hydrolase/hydrolase inhibitor PDB id
3c27

 

 

 

 

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Contents
Protein chains
26 a.a.
249 a.a. *
11 a.a. *
Ligands
DKK
Waters ×116
* Residue conservation analysis
PDB id:
3c27
Name: Hydrolase/hydrolase inhibitor
Title: Cyanofluorophenylacetamides as orally efficacious thrombin inhibitors
Structure: Thrombin light chain. Chain: a. Fragment: unp residues 334-359. Thrombin heavy chain. Chain: b. Fragment: unp residues 364-622. Engineered: yes. Hirudin-3a. Chain: h.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Resolution:
2.18Å     R-factor:   0.176     R-free:   0.215
Authors: J.C.Spurlino,M.Mcmillan,F.Lewandowski,C.Milligan
Key ref: K.D.Kreuter et al. Cyanofluorophenylacetamides as orally efficacious thrombin inhibitors. To be published, .
Date:
24-Jan-08     Release date:   17-Feb-09    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		622 a.a.
26 a.a.
Protein chain
Pfam   ArchSchema ?
P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		622 a.a.
249 a.a.
Protein chain
Pfam   ArchSchema ?
P28504  (HIR2_HIRME) -  Hirudin-2 from Hirudo medicinalis
Seq:
Struc: 		65 a.a.
11 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.3.4.21.5  - thrombin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Preferential cleavage: Arg-|-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.

 

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