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UniProt functional annotation for O35964 | ||
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| UniProt code: O35964. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}. |
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| Subunit: | |
Interacts with ARC, SYNJ1 and DNM1. Interacts with PDCD6IP (By similarity). Interacts with BIN2. {ECO:0000250, ECO:0000269|PubMed:17088211, ECO:0000269|PubMed:23285027, ECO:0000269|PubMed:9238017}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:17088211}. Early endosome membrane {ECO:0000269|PubMed:17088211}; Peripheral membrane protein {ECO:0000269|PubMed:17088211}. Cell projection, podosome {ECO:0000250}. Note=Associated with postsynaptic endosomes in hippocampal neurons. |
| Tissue specificity: | |
Detected in brain and testis (at protein level). Ubiquitous. {ECO:0000269|PubMed:23285027, ECO:0000269|PubMed:9238017}. |
| Domain: | |
An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. {ECO:0000250}. |
| Similarity: | |
Belongs to the endophilin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.