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UniProt functional annotation for Q805F6 | ||
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| UniProt code: Q805F6. |
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| Organism: | |
Agkistrodon contortrix contortrix (Southern copperhead). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Agkistrodon. |
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| Function: | |
[Snake venom metalloproteinase]: impairs hemostasis in the envenomed animal (By similarity). This product has not been identified in the venom. {ECO:0000250}. |
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| Function: | |
[Disintegrin acostatin-beta]: inhibits platelet aggregation in human platelet-rich plasma induced by ADP. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250}; |
| Subunit: | |
Heterodimer with subunit alpha; disulfide-linked (disintegrin). {ECO:0000269|PubMed:12450389, ECO:0000269|PubMed:18391413}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Miscellaneous: | |
The disintegrin belongs to the dimeric disintegrin subfamily. |
| Similarity: | |
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIe sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.