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UniProt functional annotation for Q53QZ3 | ||
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| UniProt code: Q53QZ3. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
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| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:12650940}. Membrane {ECO:0000269|PubMed:12650940}; Peripheral membrane protein {ECO:0000269|PubMed:12650940}. |
| Tissue specificity: | |
Expressed in lung, liver and lymphoid cells. {ECO:0000269|PubMed:12650940}. |
| Domain: | |
The PH domain is required for localization to the membrane. {ECO:0000269|PubMed:12650940}. |
| Sequence caution: | |
Sequence=AAF67618.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF67633.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF87324.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.