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UniProt functional annotation for Q4JB80 | ||
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| UniProt code: Q4JB80. |
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| Organism: | |
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770). |
| Taxonomy: | |
Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Sulfolobus. |
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| Function: | |
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. {ECO:0000255|HAMAP-Rule:MF_01113}. |
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| Catalytic activity: | |
Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP- Rule:MF_01113}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_01113}; Note=Binds 2 magnesium ions per subunit. {ECO:0000255|HAMAP- Rule:MF_01113}; |
| Subunit: | |
Monomer. {ECO:0000255|HAMAP-Rule:MF_01113}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01113}. |
| Similarity: | |
Belongs to the DNA polymerase type-Y family. {ECO:0000255|HAMAP-Rule:MF_01113}. |
Annotations taken from UniProtKB at the EBI.