PDBsum entry 3bp6

Signaling protein

PDB id: 3bp6

Contents

Protein chains

112 a.a. *

186 a.a. *

Ligands

GOL ×4

Waters ×278

* Residue conservation analysis

PDB id:

3bp6

Name:

Signaling protein

Title:

Crystal structure of the mouse pd-1 mutant and pd-l2 complex

Structure:

Programmed cell death protein 1. Chain: a. Fragment: extrocellular domain. Synonym: protein pd-1, mpd-1, cd279 antigen. Engineered: yes. Mutation: yes. Programmed cell death 1 ligand 2. Chain: b. Fragment: extrocellular domain.

Source:

Mus musculus. Mouse. Gene: pdcd1, pd1. Expressed in: escherichia coli. Gene: pdcd1lg2, b7dc, btdc, cd273, pdl2.

Resolution:

1.60Å R-factor: 0.186 R-free: 0.218

Authors:

Q.Yan,E.Lazar-Molnar,E.Cao,U.A.Ramagopal,R.Toro,S.G.Nathenson, S.C.Almo

Key ref:

Q.Yan et al. Crystal structure of the mouse pd-1 a99l and pd-L2 complex. To be published, .

Date:

18-Dec-07 Release date: 24-Feb-09

Protein chain

Q02242  (PDCD1_MOUSE) -  Programmed cell death protein 1 from Mus musculus

Seq: 288 a.a.

Struc: 112 a.a.*

Protein chain

Q9WUL5  (PD1L2_MOUSE) -  Programmed cell death 1 ligand 2 from Mus musculus

Seq: 247 a.a.

Struc: 186 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)