UniProt functional annotation for Q9Y2J2



	UniProt functional annotation for Q9Y2J2

UniProt code: Q9Y2J2.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.

Subunit: Interacts (via FERM domain) with CADM1. Interacts with PRMT3, PRMT5 and PRMT6. {ECO:0000269|PubMed:12234973, ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:21131357}.

Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction {ECO:0000269|PubMed:9892180}. Cell membrane {ECO:0000269|PubMed:9892180}; Peripheral membrane protein {ECO:0000269|PubMed:9892180}; Cytoplasmic side {ECO:0000269|PubMed:9892180}. Cytoplasm {ECO:0000269|PubMed:9892180}. Note=Detected in the cytoplasm of actively dividing cells.

Tissue specificity: Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung. {ECO:0000269|PubMed:9892180}.

Sequence caution: Sequence=AAC79806.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA76831.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5. {ECO:0000269\|PubMed:15334060, ECO:0000269\|PubMed:15737618, ECO:0000269\|PubMed:16420693, ECO:0000269\|PubMed:9892180}.


Subunit:		Interacts (via FERM domain) with CADM1. Interacts with PRMT3, PRMT5 and PRMT6. {ECO:0000269\|PubMed:12234973, ECO:0000269\|PubMed:15334060, ECO:0000269\|PubMed:15737618, ECO:0000269\|PubMed:21131357}.
Subcellular location:		Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction {ECO:0000269\|PubMed:9892180}. Cell membrane {ECO:0000269\|PubMed:9892180}; Peripheral membrane protein {ECO:0000269\|PubMed:9892180}; Cytoplasmic side {ECO:0000269\|PubMed:9892180}. Cytoplasm {ECO:0000269\|PubMed:9892180}. Note=Detected in the cytoplasm of actively dividing cells.
Tissue specificity:		Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung. {ECO:0000269\|PubMed:9892180}.
Sequence caution:		Sequence=AAC79806.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA76831.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};