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PDBsum entry 3bia
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Immune system
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PDB id
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3bia
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References listed in PDB file
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Key reference
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Title
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Structures of t cell immunoglobulin mucin protein 4 show a metal-Ion-Dependent ligand binding site where phosphatidylserine binds.
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Authors
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C.Santiago,
A.Ballesteros,
L.Martínez-Muñoz,
M.Mellado,
G.G.Kaplan,
G.J.Freeman,
J.M.Casasnovas.
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Ref.
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Immunity, 2007,
27,
941-951.
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PubMed id
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Abstract
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The T cell immunoglobulin and mucin domain (TIM) proteins are important
regulators of T cell responses. Crystal structures of the murine TIM-4
identified a metal-ion-dependent ligand binding site (MILIBS) in the
immunoglobulin (Ig) domain of the TIM family. The characteristic CC' loop of the
TIM domain and the hydrophobic FG loop shaped a narrow cavity where acidic
compounds penetrate and coordinate to a metal ion bound to conserved residues in
the TIM proteins. The structure of phosphatidylserine bound to the Ig domain
showed that the hydrophilic head penetrates into the MILIBS and coordinates with
the metal ion, whereas the aromatic residues on the tip of the FG loop
interacted with the fatty acid chains and could insert into the lipid bilayer.
Our results also revealed an important role of the MILIBS in the trafficking of
TIM-1 to the cell surface.
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