PDBsum entry 3bfx

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Transferase PDB id
Protein chain
253 a.a. *
A3P ×2
Waters ×512
* Residue conservation analysis
PDB id:
Name: Transferase
Title: Crystal structure of human sulfotransferase sult1c1 in complex with pap
Structure: Sulfotransferase 1c2. Chain: a, b. Synonym: sulfotransferase 1c1, sult1c#1, st1c2, humsultc2. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: sult1c2, sult1c1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
1.80Å     R-factor:   0.184     R-free:   0.227
Authors: A.Dong,L.Dombrovski,P.Loppnau,A.M.Edwards,C.H.Arrowsmith, J.Weigelt,M.Sundstrom,A.Bochkarev,A.N.Plotnikov,Structural Genomics Consortium (Sgc)
Key ref:
L.Dombrovski et al. (2006). Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). Proteins, 64, 1091-1094. PubMed id: 16804942 DOI: 10.1002/prot.21048
23-Nov-07     Release date:   04-Dec-07    
Supersedes: 2etg
Go to PROCHECK summary

Protein chains
Pfam   ArchSchema ?
O00338  (ST1C2_HUMAN) -  Sulfotransferase 1C2
296 a.a.
253 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   3 terms 
  Biological process     small molecule metabolic process   5 terms 
  Biochemical function     transferase activity     2 terms  


DOI no: 10.1002/prot.21048 Proteins 64:1091-1094 (2006)
PubMed id: 16804942  
Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).
L.Dombrovski, A.Dong, A.Bochkarev, A.N.Plotnikov.
No abstract given.

  Selected figure(s)  
Figure 1.
Figure 1. Comparison of structures of (A) SULT1C1 + PAP, (B) SULT1B1 + PAP, and (C) SULT1A1 + PAP + Estradiol (PDB ID: 2D06). The proteins are shown as a shadowed ribbon diagrams with the flexible loops colored in cyan, gold, and magenta. PAP and Estradiol are represented as a stick model colored as per atom type: carbon in yellow, oxygen in red, nitrogen in blue, and phosphorus in orange. See text for more details.
Figure 2.
Figure 2. Structure-based sequence alignment of human SULTs. Alignment was carried out by using ClustalW program with manual fittings. The fragments colored in cyan, gold, and magenta correspond to the respective loops in Figure 1. Protein sequences used in alignment: SULT1A1-NP_803880, SULT1A2-NP_001045, SULT1A3-NP_003157, SULT1B1-NP_055280, SULT1C1-NP_789795, SULT1C2-NP_006579, SULT1C3-NP_001008743, SULT1E1-NP_005411.
  The above figures are reprinted by permission from John Wiley & Sons, Inc.: Proteins (2006, 64, 1091-1094) copyright 2006.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
20361791 M.J.Bick, J.J.Banik, S.A.Darst, and S.F.Brady (2010).
Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone.
  Biochemistry, 49, 4159-4168.
PDB codes: 3mg9 3mgb 3mgc
18430142 G.E.Townsend, and D.H.Keating (2008).
Identification and characterization of KpsS, a novel polysaccharide sulphotransferase in Mesorhizobium loti.
  Mol Microbiol, 68, 1149-1164.  
18625336 P.Bojarová, and S.J.Williams (2008).
Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination.
  Curr Opin Chem Biol, 12, 573-581.  
17425406 A.Allali-Hassani, P.W.Pan, L.Dombrovski, R.Najmanovich, W.Tempel, A.Dong, P.Loppnau, F.Martin, J.Thornton, J.Thonton, A.M.Edwards, A.Bochkarev, A.N.Plotnikov, M.Vedadi, and C.H.Arrowsmith (2007).
Structural and chemical profiling of the human cytosolic sulfotransferases.
  PLoS Biol, 5, e97.
PDB codes: 1zd1 2ad1 2gwh 2h8k
17329243 R.Shi, S.S.Lamb, S.Bhat, T.Sulea, G.D.Wright, A.Matte, and M.Cygler (2007).
Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis.
  J Biol Chem, 282, 13073-13086.
PDB codes: 2ov8 2ovb 2ovf
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