|
|
||
|
|
|
|
|
UniProt functional annotation for Q9H0S4 | ||
|
|
|
|
|
|
||
| UniProt code: Q9H0S4. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors. {ECO:0000269|PubMed:15977068, ECO:0000269|PubMed:16963496}. |
|
||
| Catalytic activity: | |
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; |
| Subunit: | |
Interacts with AGO1 and AGO2. Interacts with GABARAP. Interacts with NOL8; the interaction is RNA-dependent. {ECO:0000269|PubMed:15977068, ECO:0000269|PubMed:16963496, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:20941364}. |
| Subcellular location: | |
Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16963496}. Note=Localizes in the nucleolar- organizing region during ribosome biogenesis. |
| Tissue specificity: | |
Expressed in skin, lung and breast. Also expressed in the brain. {ECO:0000269|PubMed:31256877}. |
| Similarity: | |
Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAF23354.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.