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PDBsum entry 3b7g
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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Human dead-box RNA helicase ddx20, conserved domain i (dead) in complex with amppnp (adenosine-(beta,gamma)-imidotriphosphate)
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Structure:
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Probable atp-dependent RNA helicase ddx20. Chain: a, b. Fragment: dead domain. Synonym: dead box protein 20, dead box protein dp 103, component of gems 3, gemin-3. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ddx20, dp103, gemin3. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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1.90Å
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R-factor:
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0.174
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R-free:
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0.202
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Authors:
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T.Karlberg,L.Tresaugues,C.H.Arrowsmith,H.Berglund,R.D.Busam, R.Collins,L.G.Dahlgren,A.M.Edwards,S.Flodin,A.Flores,S.Graslund, M.Hammarstrom,I.Johansson,A.Kallas,T.Kotenyova,L.Lehtio,M.Moche, M.E.Nilsson,P.Nordlund,T.Nyman,C.Persson,J.Sagemark,L.Svensson, A.G.Thorsell,S.Van Den Berg,J.Weigelt,M.Welin,L.Holmberg-Schiavone, Structural Genomics Consortium (Sgc)
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Key ref:
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P.Schütz
et al.
(2010).
Comparative structural analysis of human DEAD-box RNA helicases.
Plos One,
5,
12791-12791.
PubMed id:
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Date:
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30-Oct-07
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Release date:
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13-Nov-07
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PROCHECK
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Headers
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References
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Q9UHI6
(DDX20_HUMAN) -
Probable ATP-dependent RNA helicase DDX20 from Homo sapiens
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Seq:
Struc:
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824 a.a.
205 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class 1:
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E.C.3.6.1.15
- nucleoside-triphosphate phosphatase.
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Reaction:
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
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ribonucleoside 5'-triphosphate
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+
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H2O
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=
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ribonucleoside 5'-diphosphate
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+
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phosphate
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+
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H(+)
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Enzyme class 2:
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E.C.3.6.4.13
- Rna helicase.
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Reaction:
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ATP + H2O = ADP + phosphate + H+
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ATP
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+
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H2O
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=
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ADP
Bound ligand (Het Group name = )
matches with 81.25% similarity
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+
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phosphate
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Plos One
5:12791-12791
(2010)
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PubMed id:
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Comparative structural analysis of human DEAD-box RNA helicases.
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P.Schütz,
T.Karlberg,
S.van den Berg,
R.Collins,
L.Lehtiö,
M.Högbom,
L.Holmberg-Schiavone,
W.Tempel,
H.W.Park,
M.Hammarström,
M.Moche,
A.G.Thorsell,
H.Schüler.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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A.L.Mallam,
M.Del Campo,
B.Gilman,
D.J.Sidote,
and
A.M.Lambowitz
(2012).
Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p.
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Nature,
490,
121-125.
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PDB codes:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
