PDBsum entry 3b6e

Hydrolase

PDB id: 3b6e

Contents

Protein chain

182 a.a. *

Metals

_NA

Waters ×174

* Residue conservation analysis

PDB id:

3b6e

Name:

Hydrolase

Title:

Crystal structure of human dech-box RNA helicase mda5 (melanoma differentiation-associated protein 5), dech-domain

Structure:

Interferon-induced helicasE C domain-containing protein 1. Chain: a. Fragment: dech domain: residues 277-490. Synonym: interferon-induced with helicasE C domain protein 1, helicase with 2 card domains, helicard, melanoma differentiation- associated protein 5, mda-5, RNA helicase-dead box protein 116, murabutide down-regulated protein. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ifih1, mda5, rh116. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.60Å R-factor: 0.181 R-free: 0.204

Authors:

T.Karlberg,M.Welin,C.H.Arrowsmith,H.Berglund,R.D.Busam,R.Collins, L.G.Dahlgren,A.M.Edwards,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom, I.Johansson,A.Kallas,T.Kotenyova,L.Lehtio,M.Moche,M.E.Nilsson, P.Nordlund,T.Nyman,C.Persson,J.Sagemark,L.Svensson,A.G.Thorsell, L.Tresaugues,S.Van Den Berg,J.Weigelt,L.Holmberg-Schiavone, Structural Genomics Consortium (Sgc)

Key ref:

T.Karlberg et al. Human dech-Box RNA helicase mda5 (melanoma differentiation-Associated protein 5), Dech-Domain.. To be published, .

Date:

29-Oct-07 Release date: 13-Nov-07

Protein chain

Q9BYX4  (IFIH1_HUMAN) -  Interferon-induced helicase C domain-containing protein 1 from Homo sapiens

Seq: 1025 a.a.

Struc: 182 a.a.

Enzyme reactions

• Enzyme class: E.C.3.6.4.13 - Rna helicase.
• Reaction: ATP + H2O = ADP + phosphate + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site