UniProt functional annotation for Q99K10



	UniProt functional annotation for Q99K10

UniProt code: Q99K10.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (PubMed:23716671). The protein is involved in nervous system development. {ECO:0000269|PubMed:10892652, ECO:0000269|PubMed:15620359, ECO:0000269|PubMed:16982420, ECO:0000269|PubMed:23716671, ECO:0000269|PubMed:28841651}.

Subunit: Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C- terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with AIP1, GOPC and PDZRN3 (By similarity). Interacts with NLGN3. {ECO:0000250, ECO:0000269|PubMed:17897391, ECO:0000269|PubMed:18084303}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q62765}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62765}. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:Q62765}. Cell junction, synapse, synaptic cleft {ECO:0000250|UniProtKB:Q62765}. Cell junction, synapse, synaptic cell membrane {ECO:0000250|UniProtKB:Q62765}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1. {ECO:0000250|UniProtKB:Q62765}.

Tissue specificity: Brain and arteries (at protein level). Expressed in olfactory bulb. Detected in brain. {ECO:0000269|PubMed:11329178, ECO:0000269|PubMed:16982420, ECO:0000269|PubMed:18434543, ECO:0000269|PubMed:19926856}.

Induction: Expressed in a circadian manner in the brain with highest expression seen at Zeitgeber time (ZT) 6 hours. {ECO:0000269|PubMed:23716671}.

Disruption phenotype: No obvious phenotype, but mice present subtle behavorial changes with some deficits in spatial learning and memory. In addition, mice have reduced brain volume. Mice lacking both NLGN1 and NLGN2, or NLGN1 and NLGN3, are viable, but have impaired breathing, drastically reduced reproduction rates and striking deficits in raising their offspring. Mice lacking NLGN1, NLGN2 and NLGN3 are born at the expected Mendelian rate, but die shortly after birth due to respiratory failure. They do not show a significant change in the number of synapses, but synapse function is strongly impaired. Mice exhibit social novelty and fear-conditioning deficits and also show reduced wakefulness duration and altered EEG during wakefulness and sleep. {ECO:0000269|PubMed:16982420, ECO:0000269|PubMed:20147539, ECO:0000269|PubMed:23716671}.

Similarity: Belongs to the type-B carboxylesterase/lipase family. {ECO:0000305}.

Sequence caution: Sequence=BAC65715.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (PubMed:23716671). The protein is involved in nervous system development. {ECO:0000269\|PubMed:10892652, ECO:0000269\|PubMed:15620359, ECO:0000269\|PubMed:16982420, ECO:0000269\|PubMed:23716671, ECO:0000269\|PubMed:28841651}.


Subunit:		Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C- terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with AIP1, GOPC and PDZRN3 (By similarity). Interacts with NLGN3. {ECO:0000250, ECO:0000269\|PubMed:17897391, ECO:0000269\|PubMed:18084303}.
Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:Q62765}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q62765}. Cell junction, synapse, postsynaptic density {ECO:0000250\|UniProtKB:Q62765}. Cell junction, synapse, synaptic cleft {ECO:0000250\|UniProtKB:Q62765}. Cell junction, synapse, synaptic cell membrane {ECO:0000250\|UniProtKB:Q62765}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1. {ECO:0000250\|UniProtKB:Q62765}.
Tissue specificity:		Brain and arteries (at protein level). Expressed in olfactory bulb. Detected in brain. {ECO:0000269\|PubMed:11329178, ECO:0000269\|PubMed:16982420, ECO:0000269\|PubMed:18434543, ECO:0000269\|PubMed:19926856}.
Induction:		Expressed in a circadian manner in the brain with highest expression seen at Zeitgeber time (ZT) 6 hours. {ECO:0000269\|PubMed:23716671}.
Disruption phenotype:		No obvious phenotype, but mice present subtle behavorial changes with some deficits in spatial learning and memory. In addition, mice have reduced brain volume. Mice lacking both NLGN1 and NLGN2, or NLGN1 and NLGN3, are viable, but have impaired breathing, drastically reduced reproduction rates and striking deficits in raising their offspring. Mice lacking NLGN1, NLGN2 and NLGN3 are born at the expected Mendelian rate, but die shortly after birth due to respiratory failure. They do not show a significant change in the number of synapses, but synapse function is strongly impaired. Mice exhibit social novelty and fear-conditioning deficits and also show reduced wakefulness duration and altered EEG during wakefulness and sleep. {ECO:0000269\|PubMed:16982420, ECO:0000269\|PubMed:20147539, ECO:0000269\|PubMed:23716671}.
Similarity:		Belongs to the type-B carboxylesterase/lipase family. {ECO:0000305}.
Sequence caution:		Sequence=BAC65715.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};