UniProt functional annotation for Q9JLB9



	UniProt functional annotation for Q9JLB9

UniProt code: Q9JLB9.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans- interaction with NECTIN2 at Sertoli-spermatid junctions. Trans- interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269|PubMed:10744716, ECO:0000269|PubMed:11827984, ECO:0000269|PubMed:12121624, ECO:0000269|PubMed:12558799, ECO:0000269|PubMed:16128743}.

Subunit: Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN1, NECTIN2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with AFDN, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT. {ECO:0000269|PubMed:10744716, ECO:0000269|PubMed:11827984, ECO:0000269|PubMed:12826663, ECO:0000269|PubMed:15741237, ECO:0000269|PubMed:16128743}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:11827984}.

Tissue specificity: Ubiquitous with high expression in testes. Localized in spermatids at Sertoli-spermatid junctions. Expressed in ovarian granulosa cells, but only faintly expressed after ovulation. {ECO:0000269|PubMed:10744716, ECO:0000269|PubMed:12121624}.

Disruption phenotype: Mice show an ocular phenotype, microphthalmia, accompanied by a separation of the contact between the pigment and non- pigment cell layers of the ciliary epithelia. Male mice exhibits infertility, suggesting a role in spermatogenesis. In the hippocampus, the formation and the number of adherens junctions at the synapses is impaired, and the trajectory of mossy fiber is abnormal. {ECO:0000269|PubMed:15728677, ECO:0000269|PubMed:16300961}.

Similarity: Belongs to the nectin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans- interaction with NECTIN2 at Sertoli-spermatid junctions. Trans- interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269\|PubMed:10744716, ECO:0000269\|PubMed:11827984, ECO:0000269\|PubMed:12121624, ECO:0000269\|PubMed:12558799, ECO:0000269\|PubMed:16128743}.


Subunit:		Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN1, NECTIN2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with AFDN, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT. {ECO:0000269\|PubMed:10744716, ECO:0000269\|PubMed:11827984, ECO:0000269\|PubMed:12826663, ECO:0000269\|PubMed:15741237, ECO:0000269\|PubMed:16128743}.
Subcellular location:		Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269\|PubMed:11827984}.
Tissue specificity:		Ubiquitous with high expression in testes. Localized in spermatids at Sertoli-spermatid junctions. Expressed in ovarian granulosa cells, but only faintly expressed after ovulation. {ECO:0000269\|PubMed:10744716, ECO:0000269\|PubMed:12121624}.
Disruption phenotype:		Mice show an ocular phenotype, microphthalmia, accompanied by a separation of the contact between the pigment and non- pigment cell layers of the ciliary epithelia. Male mice exhibits infertility, suggesting a role in spermatogenesis. In the hippocampus, the formation and the number of adherens junctions at the synapses is impaired, and the trajectory of mossy fiber is abnormal. {ECO:0000269\|PubMed:15728677, ECO:0000269\|PubMed:16300961}.
Similarity:		Belongs to the nectin family. {ECO:0000305}.