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PDBsum entry 3asy
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protein Protein-protein interface(s) links
Transferase PDB id
3asy

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
201 a.a.
Waters ×82
PDB id:
3asy
Name: Transferase
Title: Ligand-free structure of uridine kinase from thermus thermophilus hb8
Structure: Uridine kinase. Chain: a, b. Synonym: cytidine monophosphokinase, uridine monophosphokinase. Engineered: yes
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: udk, ttha0578. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.40Å     R-factor:   0.233     R-free:   0.300
Authors: F.Tomoike,N.Nakagawa,S.Kuramitsu,R.Masui
Key ref: F.Tomoike et al. (2011). A single amino acid limits the substrate specificity of Thermus thermophilus uridine-cytidine kinase to cytidine. Biochemistry, 50, 4597-4607. PubMed id: 21539325
Date:
22-Dec-10     Release date:   01-Jun-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q5SKR5  (URK_THET8) -  Uridine kinase from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Seq:
Struc: 		211 a.a.
201 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.1.48  - uridine/cytidine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction:
1. uridine + ATP = UMP + ADP + H+
2. cytidine + ATP = CMP + ADP + H+
uridine
 + ATP
 = UMP
 + ADP
 + H(+)
cytidine
 + ATP
 = CMP
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
Biochemistry 50:4597-4607 (2011)
PubMed id: 21539325  
 
 
A single amino acid limits the substrate specificity of Thermus thermophilus uridine-cytidine kinase to cytidine.
F.Tomoike, N.Nakagawa, S.Kuramitsu, R.Masui.
 
  ABSTRACT  
 
No abstract given.

 

 

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