UniProt functional annotation for Q93DY9



	UniProt functional annotation for Q93DY9

UniProt code: Q93DY9.

Organism: Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1).

Taxonomy: Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales; Rhodospirillaceae; Magnetospirillum.

Function: Probably forms a large homooligomer on which other magnetosome subunits assemble. Required for formation of functional magnetosomes from pre-existing vesicles. {ECO:0000305|PubMed:21784982}.

Subunit: Forms round, 20 nm diameter complexes with a central cavity (PubMed:21784982). Probably binds MamC (Probable). Interacts with full- length Mms6 (By similarity). {ECO:0000250|UniProtKB:Q2W8Q0, ECO:0000269|PubMed:21784982, ECO:0000305|PubMed:24816605}.

Subcellular location: Magnetosome membrane {ECO:0000269|PubMed:11571158, ECO:0000269|PubMed:14766587}; Peripheral membrane protein {ECO:0000305|PubMed:14766587}. Note=Purified magnetosomes remain attached to each other (PubMed:11571158). Probably a peripheral membrane protein, it is solubilized by Tween 20 (PubMed:14766587). Forms oligomers that cover the surface of the magnetosome (By similarity). {ECO:0000250|UniProtKB:Q2W8Q0, ECO:0000269|PubMed:11571158, ECO:0000269|PubMed:14766587}.

Induction: Part of the probable 17 gene mamAB operon. {ECO:0000305|PubMed:13129949}.

Domain: Protein missing TPR1 (residues 1-41) forms an N-terminal domain of TPR 2-3 and a C-terminal domain with TPR 4-6 which can move with respect to each other, hinged at D-112. {ECO:0000269|PubMed:21784982}.

Disruption phenotype: Normal magnetic response, many fewer magnetosomes. MamC is mislocalized in punctate spots throughout the cell (PubMed:24816605). Deletion of approximately 80 kb of DNA, including this operon, leads to cells that are non-magnetic, lack internal membrane systems, grow poorly, have reduced mobility and take- up and accumulate iron poorly (PubMed:13129949). {ECO:0000269|PubMed:13129949, ECO:0000269|PubMed:24816605}.

Miscellaneous: The second most abundant protein in purified magnetosomes. {ECO:0000269|PubMed:11571158}.

Miscellaneous: This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)). {ECO:0000305|PubMed:11571158}.

Miscellaneous: Expression of just the minimal mamAB gene cluster (MGMSRv2__2365 to MGMSRv2__2381), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles. {ECO:0000269|PubMed:22043287}.

Similarity: Belongs to the magnetosome MamA family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1).
Taxonomy:		Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales; Rhodospirillaceae; Magnetospirillum.



Function:		Probably forms a large homooligomer on which other magnetosome subunits assemble. Required for formation of functional magnetosomes from pre-existing vesicles. {ECO:0000305\|PubMed:21784982}.


Subunit:		Forms round, 20 nm diameter complexes with a central cavity (PubMed:21784982). Probably binds MamC (Probable). Interacts with full- length Mms6 (By similarity). {ECO:0000250\|UniProtKB:Q2W8Q0, ECO:0000269\|PubMed:21784982, ECO:0000305\|PubMed:24816605}.
Subcellular location:		Magnetosome membrane {ECO:0000269\|PubMed:11571158, ECO:0000269\|PubMed:14766587}; Peripheral membrane protein {ECO:0000305\|PubMed:14766587}. Note=Purified magnetosomes remain attached to each other (PubMed:11571158). Probably a peripheral membrane protein, it is solubilized by Tween 20 (PubMed:14766587). Forms oligomers that cover the surface of the magnetosome (By similarity). {ECO:0000250\|UniProtKB:Q2W8Q0, ECO:0000269\|PubMed:11571158, ECO:0000269\|PubMed:14766587}.
Induction:		Part of the probable 17 gene mamAB operon. {ECO:0000305\|PubMed:13129949}.
Domain:		Protein missing TPR1 (residues 1-41) forms an N-terminal domain of TPR 2-3 and a C-terminal domain with TPR 4-6 which can move with respect to each other, hinged at D-112. {ECO:0000269\|PubMed:21784982}.
Disruption phenotype:		Normal magnetic response, many fewer magnetosomes. MamC is mislocalized in punctate spots throughout the cell (PubMed:24816605). Deletion of approximately 80 kb of DNA, including this operon, leads to cells that are non-magnetic, lack internal membrane systems, grow poorly, have reduced mobility and take- up and accumulate iron poorly (PubMed:13129949). {ECO:0000269\|PubMed:13129949, ECO:0000269\|PubMed:24816605}.
Miscellaneous:		The second most abundant protein in purified magnetosomes. {ECO:0000269\|PubMed:11571158}.
Miscellaneous:		This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4)). {ECO:0000305\|PubMed:11571158}.
Miscellaneous:		Expression of just the minimal mamAB gene cluster (MGMSRv2__2365 to MGMSRv2__2381), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles. {ECO:0000269\|PubMed:22043287}.
Similarity:		Belongs to the magnetosome MamA family. {ECO:0000305}.