UniProt functional annotation for O35464



	UniProt functional annotation for O35464

UniProt code: O35464.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000269|PubMed:16205717, ECO:0000269|PubMed:19063725, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:20881961}.

Subunit: Active as a homodimer or oligomer. The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer. Interacts with EVL. {ECO:0000269|PubMed:10993894, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:20881961}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:20881961}; Single-pass type I membrane protein {ECO:0000269|PubMed:20881961}.

Tissue specificity: Particularly high levels in spinal cord, cerebellum, metencephalon, superior and inferior colliculus, diencephalon, olfactory bulb and eye. {ECO:0000269|PubMed:16205717}.

Developmental stage: Temporally and spatially regulated during development.

Disruption phenotype: No visible phenotype. Mice are viable and fertile, and do not show any major behavioral defects. In developing cerebellum, migration of granule cells is impaired. Granule cells can form normal cell processes, but the movement of the nucleus seems to be impaired. {ECO:0000269|PubMed:16205717}.

Similarity: Belongs to the semaphorin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000269\|PubMed:16205717, ECO:0000269\|PubMed:19063725, ECO:0000269\|PubMed:20877282, ECO:0000269\|PubMed:20881961}.


Subunit:		Active as a homodimer or oligomer. The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer. Interacts with EVL. {ECO:0000269\|PubMed:10993894, ECO:0000269\|PubMed:20877282, ECO:0000269\|PubMed:20881961}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:20881961}; Single-pass type I membrane protein {ECO:0000269\|PubMed:20881961}.
Tissue specificity:		Particularly high levels in spinal cord, cerebellum, metencephalon, superior and inferior colliculus, diencephalon, olfactory bulb and eye. {ECO:0000269\|PubMed:16205717}.
Developmental stage:		Temporally and spatially regulated during development.
Disruption phenotype:		No visible phenotype. Mice are viable and fertile, and do not show any major behavioral defects. In developing cerebellum, migration of granule cells is impaired. Granule cells can form normal cell processes, but the movement of the nucleus seems to be impaired. {ECO:0000269\|PubMed:16205717}.
Similarity:		Belongs to the semaphorin family. {ECO:0000305}.