UniProt functional annotation for Q973F5



	UniProt functional annotation for Q973F5

UniProt code: Q973F5.

Organism: Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii).

Taxonomy: Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Sulfurisphaera.

Function: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Both trimeric complexes inhibit DNA ligase and both 3'-5' and 5'-3' activity of Hel308 (Hjm) helicase, but stimulate Hjc, the Holliday junction cleavage enzyme. {ECO:0000255|HAMAP-Rule:MF_00317, ECO:0000269|PubMed:18782564}.

Subunit: The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Forms dimeric complexes with PCNA1 and PCNA2, and trimeric complexes with PCNA123 and PCNA323; does not form homotrimers (PubMed:18782564). Crystal structures show a heterotetramer of 2 PCNA2 and 2 PCNA3, which would be large enough to clamp a Holliday junction (PubMed:21352919). {ECO:0000250, ECO:0000269|PubMed:18782564, ECO:0000269|PubMed:21352919}.

Similarity: Belongs to the PCNA family. {ECO:0000255|HAMAP- Rule:MF_00317}.

Annotations taken from UniProtKB at the EBI.


Organism:		Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii).
Taxonomy:		Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Sulfurisphaera.



Function:		Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Both trimeric complexes inhibit DNA ligase and both 3'-5' and 5'-3' activity of Hel308 (Hjm) helicase, but stimulate Hjc, the Holliday junction cleavage enzyme. {ECO:0000255\|HAMAP-Rule:MF_00317, ECO:0000269\|PubMed:18782564}.


Subunit:		The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Forms dimeric complexes with PCNA1 and PCNA2, and trimeric complexes with PCNA123 and PCNA323; does not form homotrimers (PubMed:18782564). Crystal structures show a heterotetramer of 2 PCNA2 and 2 PCNA3, which would be large enough to clamp a Holliday junction (PubMed:21352919). {ECO:0000250, ECO:0000269\|PubMed:18782564, ECO:0000269\|PubMed:21352919}.
Similarity:		Belongs to the PCNA family. {ECO:0000255\|HAMAP- Rule:MF_00317}.