spacer
spacer

PDBsum entry 3ah8
Go to PDB code: 
protein ligands Protein-protein interface(s) links
Signaling protein/inhibitor PDB id
3ah8

 

 

 

 

Loading ...

 
JSmol PyMol  
Contents
Protein chains
342 a.a. *
330 a.a. *
50 a.a. *
Ligands
ACE-HL2-HL2-OTH-
THC-HF2-DAM-ALA-
MAA
GDP
* Residue conservation analysis
PDB id:
3ah8
Name: Signaling protein/inhibitor
Title: Structure of heterotrimeric g protein galpha-q beta gamma in complex with an inhibitor ym-254890
Structure: Guanine nucleotide-binding protein g(i) subunit alpha- 1/guanine nucleotide-binding protein g(q) subunit alpha chimeric protein. Chain: a. Fragment: unp entry p10824 residues 2-28, unp entry p21279 residues 37-359. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1.
Source: Rattus norvegicus, mus musculus. Rat, mouse. Organism_taxid: 10116, 10090. Gene: gmhb. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Bos taurus. Bovine. Organism_taxid: 9913.
Resolution:
2.90Å     R-factor:   0.262     R-free:   0.315
Authors: A.Nishimura,K.Kitano,J.Takasaki,M.Taniguchi,N.Mizuno,K.Tago, T.Hakoshima,H.Itoh
Key ref: A.Nishimura et al. (2010). Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule. Proc Natl Acad Sci U S A, 107, 13666-13671. PubMed id: 20639466
Date:
20-Apr-10     Release date:   21-Jul-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P10824  (GNAI1_RAT) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Rattus norvegicus
Seq:
Struc: 		354 a.a.
342 a.a.*
Protein chain
Pfam   ArchSchema ?
P21279  (GNAQ_MOUSE) -  Guanine nucleotide-binding protein G(q) subunit alpha from Mus musculus
Seq:
Struc: 		359 a.a.
342 a.a.*
Protein chain
Pfam   ArchSchema ?
P62871  (GBB1_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Bos taurus
Seq:
Struc: 		340 a.a.
330 a.a.
Protein chain
Pfam   ArchSchema ?
P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus
Seq:
Struc: 		71 a.a.
50 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 159 residue positions (black crosses)

 

 
Proc Natl Acad Sci U S A 107:13666-13671 (2010)
PubMed id: 20639466  
 
 
Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.
A.Nishimura, K.Kitano, J.Takasaki, M.Taniguchi, N.Mizuno, K.Tago, T.Hakoshima, H.Itoh.
 
  ABSTRACT  
 
No abstract given.

 

 

spacer
spacer