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PDBsum entry 3ah8

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protein ligands Protein-protein interface(s) links
Signaling protein/inhibitor PDB id
3ah8
Jmol PyMol
Contents
Protein chains
342 a.a. *
330 a.a. *
50 a.a. *
Ligands
ACE-HL2-HL2-OTH-
THC-HF2-DAM-ALA-
MAA
GDP
* Residue conservation analysis
PDB id:
3ah8
Name: Signaling protein/inhibitor
Title: Structure of heterotrimeric g protein galpha-q beta gamma in with an inhibitor ym-254890
Structure: Guanine nucleotide-binding protein g(i) subunit a 1/guanine nucleotide-binding protein g(q) subunit alpha chi protein. Chain: a. Fragment: unp entry p10824 residues 2-28, unp entry p21279 37-359. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) beta-1.
Source: Rattus norvegicus, mus musculus. Rat, mouse. Organism_taxid: 10116, 10090. Gene: gmhb. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Bos taurus. Bovine. Organism_taxid: 9913.
Resolution:
2.90Å     R-factor:   0.262     R-free:   0.315
Authors: A.Nishimura,K.Kitano,J.Takasaki,M.Taniguchi,N.Mizuno,K.Tago, T.Hakoshima,H.Itoh
Key ref: A.Nishimura et al. (2010). Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule. Proc Natl Acad Sci U S A, 107, 13666-13671. PubMed id: 20639466
Date:
20-Apr-10     Release date:   21-Jul-10    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P10824  (GNAI1_RAT) -  Guanine nucleotide-binding protein G(i) subunit alpha-1
Seq:
Struc:
354 a.a.
342 a.a.*
Protein chain
Pfam   ArchSchema ?
P21279  (GNAQ_MOUSE) -  Guanine nucleotide-binding protein G(q) subunit alpha
Seq:
Struc:
359 a.a.
342 a.a.*
Protein chain
Pfam   ArchSchema ?
P62871  (GBB1_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Seq:
Struc:
340 a.a.
330 a.a.
Protein chain
Pfam   ArchSchema ?
P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Seq:
Struc:
71 a.a.
50 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 159 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell body   14 terms 
  Biological process     regulation of catenin import into nucleus   30 terms 
  Biochemical function     nucleotide binding     15 terms  

 

 
Proc Natl Acad Sci U S A 107:13666-13671 (2010)
PubMed id: 20639466  
 
 
Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.
A.Nishimura, K.Kitano, J.Takasaki, M.Taniguchi, N.Mizuno, K.Tago, T.Hakoshima, H.Itoh.
 
  ABSTRACT  
 
No abstract given.

 

 

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