PDBsum entry 3acj

Transferase

PDB id: 3acj

Contents

Protein chain

272 a.a. *

Ligands

SO4 ×2

DMS

KSS

Waters ×200

* Residue conservation analysis

PDB id:

3acj

Name:

Transferase

Title:

Crystal structure of imidazo pyrimidine derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)

Structure:

Proto-oncogene tyrosine-protein kinase lck. Chain: a. Fragment: unp residues 225-509. Synonym: lymphocyte kinase, lck, lymphocyte cell-specific protein- tyrosine kinase, p56-lck, lsk, t cell-specific protein-tyrosine kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Resolution:

2.20Å R-factor: 0.175 R-free: 0.247

Authors:

E.Tsuji

Key ref:

M.Ozawa et al. Ab initio fragment molecular orbital study of ligand binding to leukocyte-Specific protein tyrosine (lck). To be published, .

Date:

05-Jan-10 Release date: 30-Jun-10

Protein chain

P06239  (LCK_HUMAN) -  Tyrosine-protein kinase Lck from Homo sapiens

Seq: 509 a.a.

Struc: 272 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] (Bound ligand (Het Group name = KSS) matches with 40.00% similarity) + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site