UniProt functional annotation for P58546



	UniProt functional annotation for P58546

UniProt code: P58546.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. {ECO:0000250, ECO:0000269|PubMed:10329199, ECO:0000269|PubMed:16895918, ECO:0000269|PubMed:20625546}.

Subunit: Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB. {ECO:0000250, ECO:0000269|PubMed:16895918, ECO:0000269|PubMed:20625546}.

Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.

Tissue specificity: Ubiquitous. {ECO:0000269|PubMed:10329199}.

Induction: Up-regulated in heart left ventricle of patients with severe coronary artery disease and history of myocardial ischemia. Up- regulated in heart left ventricle of patients with dilated cardiomyopathy. {ECO:0000269|PubMed:10329199}.

Miscellaneous: This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN.

Similarity: Belongs to the myotrophin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. {ECO:0000250, ECO:0000269\|PubMed:10329199, ECO:0000269\|PubMed:16895918, ECO:0000269\|PubMed:20625546}.


Subunit:		Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB. {ECO:0000250, ECO:0000269\|PubMed:16895918, ECO:0000269\|PubMed:20625546}.
Subcellular location:		Cytoplasm {ECO:0000305}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
Tissue specificity:		Ubiquitous. {ECO:0000269\|PubMed:10329199}.
Induction:		Up-regulated in heart left ventricle of patients with severe coronary artery disease and history of myocardial ischemia. Up- regulated in heart left ventricle of patients with dilated cardiomyopathy. {ECO:0000269\|PubMed:10329199}.
Miscellaneous:		This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN.
Similarity:		Belongs to the myotrophin family. {ECO:0000305}.