UniProt functional annotation for Q571K4



	UniProt functional annotation for Q571K4

UniProt code: Q571K4.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys- 63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. {ECO:0000250|UniProtKB:Q8N5C8}.

Subunit: Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with DYNC2I2 (via the WD domains). Interacts with RBCK1. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with TRIM5. {ECO:0000250|UniProtKB:Q8N5C8}.

Domain: The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins. {ECO:0000269|PubMed:19927120}.

Ptm: Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. {ECO:0000250|UniProtKB:Q8N5C8}.

Ptm: Phosphorylated at Ser-510 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. {ECO:0000250|UniProtKB:Q8N5C8}.

Sequence caution: Sequence=BAD90370.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys- 63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. {ECO:0000250\|UniProtKB:Q8N5C8}.


Subunit:		Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with DYNC2I2 (via the WD domains). Interacts with RBCK1. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with TRIM5. {ECO:0000250\|UniProtKB:Q8N5C8}.
Domain:		The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins. {ECO:0000269\|PubMed:19927120}.
Ptm:		Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. {ECO:0000250\|UniProtKB:Q8N5C8}.
Ptm:		Phosphorylated at Ser-510 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. {ECO:0000250\|UniProtKB:Q8N5C8}.
Sequence caution:		Sequence=BAD90370.1; Type=Erroneous initiation; Evidence={ECO:0000305};