UniProt functional annotation for Q6ZPF3



	UniProt functional annotation for Q6ZPF3

UniProt code: Q6ZPF3.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. {ECO:0000269|PubMed:10364228, ECO:0000269|PubMed:11707441, ECO:0000269|PubMed:12912917, ECO:0000269|PubMed:14550769, ECO:0000269|PubMed:17320046}.

Subunit: Interacts with MAP1A, MAP1B, PARP1 and YWHAE. Interacts with CD44, PARD3 and MAPK8IP2. {ECO:0000269|PubMed:17320046, ECO:0000269|PubMed:19893486}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:14550769}. Cell projection, lamellipodium {ECO:0000269|PubMed:14550769}. Cell projection, filopodium {ECO:0000269|PubMed:14550769}. Cell projection, growth cone {ECO:0000269|PubMed:11707441, ECO:0000269|PubMed:14550769}. Cell projection, neuron projection {ECO:0000269|PubMed:11707441, ECO:0000269|PubMed:14550769}. Perikaryon {ECO:0000269|PubMed:11707441}.

Tissue specificity: Expressed in fetal brain (at protein level). Expressed in the olfactory bulb, cortical plate of the cerebral cortex, caudate putamen, hippocampus, ependymal cells of the lateral surface of the lateral ventricles of the brain. Weakly expressed in heart, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269|PubMed:10364228, ECO:0000269|PubMed:10512681, ECO:0000269|PubMed:11707441, ECO:0000269|PubMed:11900975, ECO:0000269|PubMed:12912917, ECO:0000269|PubMed:14550769}.

Developmental stage: Expressed in cerebral cortex, predominantly in the cortical plate and intermediate zone and weakly in the ventricular zone, in neurites and the growth cone of neurites of the hippocampus at 15 dpc (at protein level). Expressed in embryo at 7, 11, 15 and 17 dpc. Expressed in the preplate which consists of the Cajal-Retzius cells and the precursors of subplate neurons, in neurons of the telecephalon, in primordia of cerebral cortex and hippocampus at 12 dpc. Expressed in the cortical plate, striatum and fourth ventricle of the brain, in the cartilaginous tissues including Meckel, costal, vertebral and tracheal cartilage at 14.5 dpc. Expressed in cerebral cortex, hippocampus, olfactory bulbs, rostral migratory pathway and the striatum at 17 dpc. {ECO:0000269|PubMed:10364228, ECO:0000269|PubMed:10512681, ECO:0000269|PubMed:11707441, ECO:0000269|PubMed:11900975, ECO:0000269|PubMed:12912917}.

Domain: The PH 1 domain and amino acids 619-780 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite- like structure.

Ptm: Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1662 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth. {ECO:0000269|PubMed:17320046}.

Similarity: Belongs to the TIAM family. {ECO:0000305}.

Sequence caution: Sequence=BAC98284.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. {ECO:0000269\|PubMed:10364228, ECO:0000269\|PubMed:11707441, ECO:0000269\|PubMed:12912917, ECO:0000269\|PubMed:14550769, ECO:0000269\|PubMed:17320046}.


Subunit:		Interacts with MAP1A, MAP1B, PARP1 and YWHAE. Interacts with CD44, PARD3 and MAPK8IP2. {ECO:0000269\|PubMed:17320046, ECO:0000269\|PubMed:19893486}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:14550769}. Cell projection, lamellipodium {ECO:0000269\|PubMed:14550769}. Cell projection, filopodium {ECO:0000269\|PubMed:14550769}. Cell projection, growth cone {ECO:0000269\|PubMed:11707441, ECO:0000269\|PubMed:14550769}. Cell projection, neuron projection {ECO:0000269\|PubMed:11707441, ECO:0000269\|PubMed:14550769}. Perikaryon {ECO:0000269\|PubMed:11707441}.
Tissue specificity:		Expressed in fetal brain (at protein level). Expressed in the olfactory bulb, cortical plate of the cerebral cortex, caudate putamen, hippocampus, ependymal cells of the lateral surface of the lateral ventricles of the brain. Weakly expressed in heart, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269\|PubMed:10364228, ECO:0000269\|PubMed:10512681, ECO:0000269\|PubMed:11707441, ECO:0000269\|PubMed:11900975, ECO:0000269\|PubMed:12912917, ECO:0000269\|PubMed:14550769}.
Developmental stage:		Expressed in cerebral cortex, predominantly in the cortical plate and intermediate zone and weakly in the ventricular zone, in neurites and the growth cone of neurites of the hippocampus at 15 dpc (at protein level). Expressed in embryo at 7, 11, 15 and 17 dpc. Expressed in the preplate which consists of the Cajal-Retzius cells and the precursors of subplate neurons, in neurons of the telecephalon, in primordia of cerebral cortex and hippocampus at 12 dpc. Expressed in the cortical plate, striatum and fourth ventricle of the brain, in the cartilaginous tissues including Meckel, costal, vertebral and tracheal cartilage at 14.5 dpc. Expressed in cerebral cortex, hippocampus, olfactory bulbs, rostral migratory pathway and the striatum at 17 dpc. {ECO:0000269\|PubMed:10364228, ECO:0000269\|PubMed:10512681, ECO:0000269\|PubMed:11707441, ECO:0000269\|PubMed:11900975, ECO:0000269\|PubMed:12912917}.
Domain:		The PH 1 domain and amino acids 619-780 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite- like structure.
Ptm:		Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1662 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth. {ECO:0000269\|PubMed:17320046}.
Similarity:		Belongs to the TIAM family. {ECO:0000305}.
Sequence caution:		Sequence=BAC98284.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};