UniProt functional annotation for P21964

UniProt code: P21964.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Catalytic activity: S-adenosyl-L-methionine + a catechol = S- adenosyl-L-homocysteine + a guaiacol.
Cofactor: Binds 1 magnesium ion per subunit.
Subcellular location: Isoform Soluble: Cytoplasm.
Subcellular location: Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side.
Tissue specificity: Brain, liver, placenta, lymphocytes and erythrocytes.
Ptm: The N-terminus is blocked.
Mass spectrometry: Mass=24352; Mass_error=2; Method=Electrospray; Range=52-271; Source=PubMed:8020475;
Polymorphism: Two alleles, COMT*1 or COMT*H with Val-158 and COMT*2 or COMT*L with Met-158 are responsible for a three to four- fold difference in enzymatic activity.
Polymorphism: Low enzyme activity alleles are associated with genetic susceptibility to alcoholism [MIM:103780].
Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family.

Annotations taken from UniProtKB at the EBI.