PDBsum entry 3a5k

Hydrolase

PDB id: 3a5k

Contents

Protein chain

281 a.a. *

Metals

_MG

Waters ×197

* Residue conservation analysis

PDB id:

3a5k

Name:

Hydrolase

Title:

Crystal structure of protein-tyrosine phosphatase 1b

Structure:

Tyrosine-protein phosphatase non-receptor type 1. Chain: a. Fragment: unp residues 2-298. Synonym: protein-tyrosine phosphatase 1b, ptp-1b. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.85Å R-factor: 0.191 R-free: 0.233

Authors:

S.Ito

Key ref:

N.Iwamoto et al. Post-Translational modification of a non-Catalytic cy ptp1b. To be published, .

Date:

08-Aug-09 Release date: 11-Aug-10

Protein chain

P18031  (PTN1_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 1 from Homo sapiens

Seq: 435 a.a.

Struc: 281 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site