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PDBsum entry 3zme

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protein ligands metals Protein-protein interface(s) links
Cell cycle PDB id
3zme
Jmol
Contents
Protein chains
195 a.a.
Ligands
QC5 ×2
Metals
_ZN ×2
Waters ×512
PDB id:
3zme
Name: Cell cycle
Title: Structure of the p53 core domain mutant y220c bound to the small molecule phikan7242
Structure: Cellular tumor antigen p53. Chain: a, b. Fragment: DNA-binding domain, residues 94-312. Synonym: antigen ny-co-13, phosphoprotein p53, tumor suppre engineered: yes. Mutation: yes
Source: Synthetic: yes. Homo sapiens. Organism_taxid: 9606. Human
Resolution:
1.35Å     R-factor:   0.155     R-free:   0.175
Authors: A.C.Joerger,R.Wilcken
Key ref: X.Liu et al. (2013). Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res, 41, 6034-6044. PubMed id: 23630318 DOI: 10.1093/nar/gkt305
Date:
07-Feb-13     Release date:   08-May-13    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P04637  (P53_HUMAN) -  Cellular tumor antigen p53
Seq:
Struc:
393 a.a.
195 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     apoptotic process   2 terms 
  Biochemical function     transcription regulatory region DNA binding     3 terms  

 

 
DOI no: 10.1093/nar/gkt305 Nucleic Acids Res 41:6034-6044 (2013)
PubMed id: 23630318  
 
 
Small molecule induced reactivation of mutant p53 in cancer cells.
X.Liu, R.Wilcken, A.C.Joerger, I.S.Chuckowree, J.Amin, J.Spencer, A.R.Fersht.
 
  ABSTRACT  
 
No abstract given.